Abstract: Fish secrete different kinds of antimicrobial peptides (AMPs) which are positively charged short amino-acid-chain molecules involved in host defense mechanism. AMPs as the research hotspots in immunology are shown to have many advantages including broad-spectrum antibiotics, good thermal stability and unique antibacterial mechanism. The research progress of fish AMPs major fimctions is reviewed in this paper and its application perspective is also discussed.

Key words: fish, antimicrobial peptide, function, application perspective